Epirubicin

Epirubicin - Wikipedia, the free encyclopedia

Epirubicin is an anthracycline drug used for chemotherapy. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin "Ebewe" elsewhere.

Epirubicin 是一種chemotherapy(化療)用的anthracycline(蔥環類)藥物. 本藥由Pfizer(輝瑞)以藥品名Ellence在美國行銷. 其他區域則以 Pharmorubicin 或 Epirubicin 為名販售.

Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage.

一如其他的蔥環類藥物, Epirubicin 以嵌入DNA 方式運作, 抑制 DNA 與RNA 生產. Epirubicin 也引發 DNA 斷裂(by topoisomerase II), 導致細胞死亡. 他的細胞毒性可能與他與細胞膜或血漿蛋白結合相關. Epirubicin 也產生使致細胞與DNA 損壞的自由基.

Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar, which may account for its faster elimination and reduced toxicity. Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer, and lymphomas.

因為較少的副作用, 在某些化療法裡 Epirubicin 較 doxorubicin 受到青睞. 因為 4' carbon of the sugar 中的氫氧根有著不同的方向可能是他快速消失與低毒性的因素. Epirubicin 主要用於乳, 卵巢, 胃, 肺, 淋巴部位癌症.